top of page
Search

Salecan® Beta-Glucan: A Scientific Breakthrough for Sensitive and Atopic Skin



In the skincare industry, β-glucan has long been hailed as a "biological gold" for its remarkable bioactive properties. Among various types of β-glucan, Salecan® Beta-Glucan stands out as a third-generation innovation. YHKCare’s SenRelief Series leverages the advanced properties of Salecan® Beta-Glucan to deliver targeted solutions for sensitive and atopic skin. This article explores its science-backed mechanisms and explains why it redefines standards for fragile skin care.


I. How Does β-Glucan Benefit the Skin?

β-glucan, a natural polysaccharide found in microorganisms, plants, and fungi, delivers multifunctional skincare benefits:

  1. Deep Hydration: Forms hydrogen bonds to retain moisture and create a protective film on the skin’s surface, reducing trans-epidermal water loss (TEWL).

  2. Anti-Inflammatory Soothing: Activates macrophages and dendritic cells to suppress inflammatory cytokines (e.g., IL-6, TNF-α), alleviating redness and irritation.

  3. Barrier Repair: Stimulates keratinocyte proliferation and collagen synthesis, accelerating wound healing and reinforcing the stratum corneum.

  4. Antioxidant Protection: Neutralizes reactive oxygen species (ROS), mitigating UV-induced oxidative stress.

However, not all β-glucans are equal. While oat β-glucan and yeast-derived variants are widely used, their molecular structure, purity, and functional performance differ significantly from Salecan®.


II. The Science Behind Salecan® Beta-Glucan

Salecan® is a third-generation β-1,3/1,6-D-glucan, engineered through patented microbial fermentation (ZX09 strain). Its key advantages include:

1. Precision in Molecular Structure

  • High β-1,3-D-glucan content (75%), far exceeding oat β-glucan (30%), which enhances bioactivity.

  • Controlled molecular weight (2–2.5 million Da), balancing penetration and film-forming properties to activate repair pathways in the dermis.

2. High Purity and Low Irritation Risk

  • Ultra-low impurities (protein ≤1%, ash ≤5%), minimizing allergic reactions.

  • Naturally water-soluble without chemical modification, ensuring 3x higher permeability than oat β-glucan.

3. Clinical Efficacy Validation

  • WCH Medical Center Study (2016): After 4 weeks of use, epidermal hydration increased by 40%, and TEWL decreased by 25%.

  • Zebrafish Wound Healing Model (2024): At 1,000 μg/mL concentration, Salecan® improved wound closure by 22% and vascular regeneration by 80%, surpassing oat β-glucan.

4. Stability and Versatility

  • Industrial production ensures pH/heat stability, with a shelf life of 24 months.

  • Compatible with diverse formulations (serums, moisturizers, masks) and well-tolerated by compromised skin.


III. Why Salecan® Outperforms Oat Beta-Glucan

Characteristic

Salecan® Beta-Glucan

Oat Beta-Glucan

Source

Patent marine microbial fermentation (ZX09)

Oat bran extraction

β-1,3-D-glucan Ratio

75% (core active ingredient)

30%

Molecular Weight Range

2–2.5 million Da (balanced penetration + film-forming)

5,300–257,200 Da (short-chain dominated)

Water Solubility

Naturally soluble, no additives required

Poor solubility; requires hydroxyethyl cellulose

Antioxidant Activity

>98% cell survival after UVA exposure

Limited antioxidant capacity

Impurity Content

Protein ≤1%, ash ≤5%

Protein ≥5%, ash ≥10%

Clinical Data

Human trials (n=31) show p<0.05 improvement

Animal studies; limited clinical evidence

Cost

High

Low


IV. Why Choose Salecan® Beta-Glucan?

  1. Safer for Sensitive Skin: Oat β-glucan often requires hydroxyethyl cellulose to improve solubility, potentially irritating sensitive skin. Salecan® is free from alcohol, fragrances, and preservatives.

  2. Faster Barrier Repair: Achieves effective concentration (0.2%) at 1%, penetrating the dermis to accelerate repair.

  3. Adaptable to Multiple Needs: Ideal for daily hydration, post-sunburn relief, and post-procedure recovery, especially for atopic or barrier-damaged skin.


V. Recommended Usage & Synergy Combinations

  1. Daily Maintenance: Apply serum after cleansing, followed by a moisturizer to lock in hydration.

  2. Emergency Care: For redness or irritation, apply a thick layer of essence for 10 minutes, then gently press into skin.

  3. Synergistic Pairings:

    • Niacinamide: Combats hyperpigmentation while supporting barrier function.


VI. Conclusion

Salecan® Beta-Glucan redefines standards for sensitive and atopic skin care through precision engineering, high purity, and clinical validation. Compared to traditional oat β-glucan, it offers unmatched efficacy in hydration, anti-inflammation, and barrier repair. For those struggling with eczema, seasonal sensitivity, or compromised skin health, Salecan® is a scientifically proven solution to restore resilience and radiance.

Empower your skin with nature-driven science—where innovation meets safety.


References

  1. WCH Medical Center Report on Hydration & Safety Evaluation (2016)

  2. Zebrafish Wound Healing Model Data (2024)

  3. Journal of Dermatological Treatment – β-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis (PubMed ID: 26654776)

 
 
 

Comentarios

bottom of page