Gentle Repair, Rooted in Understanding: The Role of SenRelief B+3 Essence in Sensitive Skin Care

In today’s saturated skincare market, what truly resonates with people is often not flashy marketing, but a genuine story about why something was created. SenRelief B+3 Essence is one such product — born from care and concern.

Its original development was not driven by market trends or business strategies, but by a father’s struggle with his child's food sensitivities and recurring eczema. Frustrated by the lack of safe, long-term solutions — many products were either too complex, irritating, or contained allergens — he decided to take matters into his own hands. With expert guidance, he developed this gentle yet effective essence, specially formulated for sensitive skin.

Natural Ingredients + Scientific Innovation | Seven Key Ingredients Targeting the Root of Sensitivity

SenRelief B+3 Essence combines plant-based extracts with modern biotechnology to soothe sensitivity, reduce inflammation, strengthen the skin barrier, and support repair:

• Jasmine Cellsap

Rich in amino acids and polysaccharides, it provides strong hydration and antioxidant benefits, helping to improve dryness and flaking commonly seen in eczema.

• Beta-Glucan

Boosts skin immunity and activates the self-repair mechanisms of keratinocytes, enhancing resistance to external irritants — ideal for long-term damaged skin.

• Vitamin B3 (Niacinamide)

Strengthens the epidermal barrier, reduces transepidermal water loss (TEWL), and has anti-inflammatory and immune-regulating properties.

• Sophora Flavescens Extract (Ku Shen)

Traditionally used in Chinese medicine for clearing heat and detoxifying, modern studies show it effectively inhibits histamine release and inflammatory factors like IL-6.

• DICTAMNUS DASYCARPUS ROOT BARK EXTRACT (Bai Xian Pi)

Known for its antibacterial, antiallergic, and itch-relieving effects, it’s especially suitable for eczema and other itchy skin conditions.

• KOCHIA SCOPARIA EXTRACT (Di Fu Zi)

Clears heat, relieves dampness, and soothes itching — often used to treat skin irritation and eczema with noticeable soothing effects.

• Ectoin (Skin Complexion Enhancer)

A natural compatible solute derived from extremophiles, Ectoin stabilizes cell membranes under stress. In skincare, it prevents moisture loss, strengthens the stratum corneum, and suppresses histamine release by stabilizing mast cells — effectively reducing redness and itching. Its unique “molecular shield” mechanism makes it a standout ingredient for eczema and sensitive skin.

Scientifically Validated | Data-Driven Evidence of Efficacy and Safety

To ensure the effectiveness and safety of SenRelief B+3 Essence, we collaborated with professional laboratories to conduct multi-dimensional testing across five key areas: anti-allergy, anti-inflammation, hydration, repair, and soothing.

1. Tryptase Expression Test (Anti-Allergy Efficacy)

• Significance: Tryptase is a key mediator released by mast cells during allergic reactions.

• Result: Tryptase expression decreased by 93%, showing that the product effectively inhibits the onset of allergic reactions and alleviates symptoms such as redness and itching caused by eczema.

2. Anti-Inflammatory Test (IL-6 Inhibition Rate)

• Significance: IL-6 is a pro-inflammatory cytokine that is often elevated in eczema patients, worsening localized inflammation.

• Result: SenRelief B+3 Essence significantly reduced IL-6 levels, demonstrating strong anti-inflammatory action and helping to control acute flare-ups.

3. Stratum Corneum Moisture Content Test (Hydration Efficacy)

• Significance: Eczema-prone skin often suffers from impaired barrier function and excessive water loss.

• Result: Skin moisture increased by 45.87% after 4 hours and 48.92% after 8 hours, indicating strong hydrating power that helps restore a healthy skin barrier.

4. Wound Healing Assay (HaCaT Scratch Model)

• Significance: HaCaT cells are immortalized human keratinocytes; scratch assays simulate skin wound healing.

• Result: The product accelerated cell migration by up to 72%, proving its strong regenerative potential and ability to aid in barrier reconstruction.

5. Zebrafish MPX Model (Soothing Efficacy vs. Hydrocortisone Cream 1%)

• Significance: Myeloperoxidase (MPX) activity reflects neutrophil presence and inflammation levels.

• Result: SenRelief B+3 Essence showed comparable soothing efficacy to 1% hydrocortisone cream, confirming its powerful anti-inflammatory and calming effect on irritated skin.

6. Zebrafish Pediatric Cosmetic Safety Assessment

• Significance: Evaluates product safety for infants using zebrafish embryo models.

• Result: No embryotoxicity or developmental abnormalities were observed, confirming the formulation is mild and non-irritating — suitable for children and sensitive skin types.

7. German Dermatest Sensitive Skin Patch Test & Certification

• Significance: One of the most recognized dermatological certifications for sensitive skin products.

• Result: Successfully passed the sensitive skin patch test, confirming the product is non-irritating and safe for use on sensitive skin.

Conclusion: A Trusted Partner in Sensitive Skin Care

SenRelief B+3 Essence is more than just a moisturizing essence — it’s a scientifically backed solution designed for real-life needs. Through a combination of gentle ingredients and proven results, it supports sensitive and inflamed skin on the path to recovery, making it a reliable companion for daily home care.

【Real User Feedback】

@cosme users reported 100% satisfaction with the soothing and repairing effects of the product.

Based on a post-use satisfaction survey conducted by @cosme in February 2025 on the YHKCare SenRelief® Soothing Essence + Deep Hydrating Cream set, with 36 valid responses collected.